Rheology of Drugs For Topical and Transdermal Delivery
نویسندگان
چکیده
منابع مشابه
Skin electroporation for transdermal and topical delivery.
Electroporation is the transitory structural perturbation of lipid bilayer membranes due to the application of high voltage pulses. Its application to the skin has been shown to increase transdermal drug delivery by several orders of magnitude. Moreover, electroporation, used alone or in combination with other enhancement methods, expands the range of drugs (small to macromolecules, lipophilic ...
متن کاملTopical and transdermal delivery of L-carnitine.
BACKGROUND The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen species, enhanced matrix metalloproteinase expression and decreased procollagen synthesis. L-Carnitine L-tartrate has been reported to have anti-aging effects. AIM AND METHODS Th...
متن کاملInnovative Strategies for Enhancing Topical and Transdermal Drug Delivery
Abstact: Historically, the skin was thought to be a simple homogenous barrier. However, it is now known to be a highly specialised organ, and plays a key role in homeostasis. The protective properties of the skin are provided by the outermost layer, the epidermis, which safeguards against chemical, microbial, and physical attack. The exceptional barrier properties of the skin result in it being...
متن کاملDrug crystallization - implications for topical and transdermal delivery.
INTRODUCTION Crystallization of actives in skin following topical application was suggested by studies in the 1950s and 1960s but is poorly understood. In contrast, the problem of crystallization of actives on skin and in transdermal formulations has been known for many years. AREAS COVERED With respect to crystallization in skin, this review describes early reports of a skin 'reservoir' and ...
متن کاملTopical Antiacne Drugs Delivery Systems
Received: August 23, 2016 Revised: September 10, 2016 Accepted: October 03, 2016 Abstract: Background: Acne vulgaris (commonly called acne) is the most prevalent skin complication of different causes with a higher prevalence in adolescents. Topical administration is used as first-choice therapy in mild acne, whereas for moderate and severe acne, systemic administration is required in addition t...
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ژورنال
عنوان ژورنال: International Journal of Applied Mechanics and Engineering
سال: 2019
ISSN: 2353-9003,1734-4492
DOI: 10.2478/ijame-2019-0012